Director, Translational Medicine Expert (Neurodegeneration)

Salary Range:
£96,036.50 - £178,353.50 
Job Description Summary
#LI-Hybrid Internal job title: Director Location: London, UKThe Director, Translational Medicine Expert (Neurodegeneration) will lead the end to end translational strategy for neurodegenerative programs, bridging preclinical research to early clinical development (Phase 1–2).This role is accountable for biomarker strategy, clinical endpoint selection, and early phase trial design, enabling efficient, data driven decision-making through key development milestones (e.g., Transition Decision Points) and ensuring competitive differentiation of neuromuscular assets.In addition, he/she oversees the planning, execution, and interpretation of clinical trials research, data collection activities and clinical operations. Establishes and approves scientific methods for design and implementation of clinical protocols, data collection systems and final reports. Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements 
Job Description
Key Responsibilities:
1. Translational Strategy & Program Leadership
Define and execute integrated translational strategies across neurodegeneration programs
Lead translational components from preclinical → Phase 1/2 clinical studies
Drive program progression through key decision gates (e.g., IND, TDP, IDPA)
Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints

2. Biomarker & Endpoint Leadership
Collaborate with Biomarker Development colleagues toward development and validation of:Molecular biomarkers (tissue, blood, CSF where applicable)
Functional endpoints (strength, mobility, disease-specific measures)
Patient-reported outcomes (PROs)
Establishing quantitative biomarkers to support:Target engagement
Disease modification
Dose selection and PoC decisions

Integrate biomarker strategy into clinical protocols and operational plans
Drive early biomarker de‑risking, a key priority in neuromuscular programs

3. Early Clinical Development (Phase 1/2)
Co‑lead design and execution of early clinical studies
Define:Dose escalation strategy
Exposure–response framework
Translational endpoints (biopsy, imaging, functional)

Ensure TM leadership within Clinical Trial Teams (CTTs) for:Trial design
Execution oversight
Data interpretation and decision-making

4. Cross-Functional Leadership
Serve as core Translational Medicine representative within global project teams
Partner closely with:Clinical Development
Biomarker Development
Clinical Pharmacology (PKS)
Preclinical Safety (PCS)
Regulatory

Drive alignment between research, TM, and development organizations

5. External Scientific Leadership
Build and lead collaborations with:Academic KOLs
Patient advocacy groups (critical in rare neuromuscular disease)
Technology partners (imaging, omics platforms)

Contribute to scientific strategy and external positioning of programs

6. Patient-Centered Development
Integrate the patient voice into translational and clinical strategies
Advance:Meaningful functional endpoints
Patient-relevant outcome measures
Innovative trial approaches (e.g., decentralized models where feasible)

7. Portfolio Contribution & Strategic Input
Contribute to:Asset prioritization and portfolio strategy
Competitive differentiation strategy (e.g., vs RNA or gene therapy competitors)

Provide scientific input to:Business development / due diligence
Indication expansion strategies

Essential Requirements:
·       MD, neurologists, clinical training in neurodegenerative diseases
·       Experience in translational medicine, early clinical development, or experimental therapeutics.
·       Ability to shape development strategies, execute early clinical studies, and influence regulatory/packages supporting differentiation.
Desirable Requirements:
·       Experience working in pharmaceutical/biotech company strongly preferred.
·       PhD, PharmD, or equivalent in:
o   Neurology / Neuroscience
o   Neurodegenerative diseases
Benefits & Rewards 
At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen. 
  
Expected Annual Base Salary Range for role: £96,036.50 - £178,353.50 GBP
The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically. 
  
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. 
  
The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave. 
  
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Long-term equity awards granted at group level may also be part of your package. Further details will be provided during the application process.  
You may be eligible for a company vehicle or a car allowance in accordance with the applicable local Novartis policies and guidelines. 
Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics. 
  
Read our brochure to learn more about our global total rewards offering: 
  
https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf 
  
Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process. 
Commitment to Diversity and Inclusion / EEO  
Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Benefits and Rewards: Learn about all the ways we’ll help you thrive personally and professionally.Read our handbook (PDF 30 MB)
 
Skills Desired
Clinical Trials, Data Analysis, Data Monitoring, Drug Development, Medical Research, People Management